diltizem - is broken down by the same enzyme. Therefore, in transplantation medicine you give a cardiac drug! (diltiazem) because it means that the blood levels of Cya will be higher and therefore you can lower the dose that you give.
digoxin - is secreted out by kidney cells into the urine. Cyclosporin, 'cos it screws around with cells, stops this. This was first discovered when some cardiac transplant patients suddenly developed digoxin toxicity.
allopurinol - CyA levels go sky high when patients are started on allopurinol. No idea why.
phenytoin - ramps up the liver and so more CyA gets chewed up and CyA blood levels fall.
So, the important message is that if someone is on CyA then there will probably be a drug interaction with some of the other drugs they are on, and you should always check for what this interaction will be, before prescribing.
No comments:
Post a Comment